Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC041
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-28 14:09
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 250mg 1/2,1/4,1/2,1/4 caps Madopsr HBS125mg 2x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 36 individuals with a value less than 0.69 were subsequently diagnosed with PD. That is, 85.71% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.69 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 3, 'TN': 4, 'TP': 39, 'FP': 26}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 39, 'TN': 29, 'TP': 3, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 6.764
timePerCircleCoV 0.512975
timePerCircleSlope -0.161174
meanError 1.91511
tremorFreq 5.76172
tremorRelPower 31.9966
tremorGyroAmpMean 0.129789
tremorGyroAmpSlope 0.0272065
tremorGyroAmpCoV 0.522922
tremorCoordAmpMean 0.253113
tremorCoordAmpSlope 0.0335832
tremorCoordAmpCoV 0.591338
tremorAccAmpMean 0.261338
tremorAccAmpSlope 0.025168
tremorAccAmpCoV 0.427462
tremorPcRelVar 0.84857
tremorPcX 0.148425
tremorPcY 0.988924

Circle Segment 1

Duration 13.0 s, Accuracy Estimate 2.059 (lower is better)

Circle Segment 2

Duration 11.76 s, Accuracy Estimate 1.188 (lower is better)

Circle Segment 3

Duration 8.44 s, Accuracy Estimate 1.066 (lower is better)

Circle Segment 4

Duration 8.2 s, Accuracy Estimate 1.637 (lower is better)

Circle Segment 5

Duration 6.0 s, Accuracy Estimate 1.545 (lower is better)

Circle Segment 6

Duration 5.04 s, Accuracy Estimate 2.389 (lower is better)

Circle Segment 7

Duration 4.2 s, Accuracy Estimate 1.953 (lower is better)

Circle Segment 8

Duration 4.24 s, Accuracy Estimate 2.214 (lower is better)

Circle Segment 9

Duration 3.72 s, Accuracy Estimate 2.31 (lower is better)

Circle Segment 10

Duration 3.04 s, Accuracy Estimate 2.791 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 8.98
timePerSpiralCoV 0.390753
timePerSpiralSlope -0.190773
meanError 2.81463
tremorFreq 6.34766
tremorRelPower 34.3413
tremorGyroAmpMean 0.179625
tremorGyroAmpSlope 0.00902061
tremorGyroAmpCoV 0.5569
tremorCoordAmpMean 0.354544
tremorCoordAmpSlope 0.0123022
tremorCoordAmpCoV 0.423287
tremorAccAmpMean 0.309274
tremorAccAmpSlope 0.0101426
tremorAccAmpCoV 0.407363
tremorPcRelVar 0.879771
tremorPcX -0.0588145
tremorPcY 0.998269

Spiral Segment 1

Duration 14.8 s, Accuracy Estimate 2.297 (lower is better)

Spiral Segment 2

Duration 11.4 s, Accuracy Estimate 2.489 (lower is better)

Spiral Segment 3

Duration 8.72 s, Accuracy Estimate 1.968 (lower is better)

Spiral Segment 4

Duration 6.6 s, Accuracy Estimate 3.488 (lower is better)

Spiral Segment 5

Duration 5.72 s, Accuracy Estimate 3.389 (lower is better)

Spiral Segment 6

Duration 6.64 s, Accuracy Estimate 3.256 (lower is better)

Elel

eDurationMean 0.173485
eDurationStd 0.0286816
eDurationStdnorm 0.165326
eDurationMedian 0.175
eDurationQuartdelta 0.04625
eDurationQuartdeltanorm 0.264286
eDurationKurt 2.21232
eDurationTrenddiff -0.025
eDurationTrendratio 0.864865
eWidthMean 1.68409
eWidthStd 0.54717
eWidthStdnorm 0.324905
eWidthMedian 1.638
eWidthQuartdelta 0.7605
eWidthQuartdeltanorm 0.464286
eWidthKurt 3.33363
eWidthTrenddiff 0.117
eWidthTrendratio 1.07407
eHeightMean 4.50627
eHeightStd 1.09331
eHeightStdnorm 0.242619
eHeightMedian 4.68
eHeightQuartdelta 1.72575
eHeightQuartdeltanorm 0.36875
eHeightKurt 2.72759
eHeightTrenddiff 0.117
eHeightTrendratio 1.02597
eAspectMean 0.375324
eAspectStd 0.0811946
eAspectStdnorm 0.216332
eAspectMedian 0.375
eAspectQuartdelta 0.112069
eAspectQuartdeltanorm 0.298851
eAspectKurt 3.2103
eAspectTrenddiff 0.0419451
eAspectTrendratio 1.11531
eSlantMean -0.037097
eSlantStd 0.237361
eSlantStdnorm -6.39839
eSlantMedian 0.0357143
eSlantQuartdelta 0.294892
eSlantQuartdeltanorm 8.25697
eSlantKurt 3.14794
eSlantTrenddiff 0.0185185
eRtopMean 0.797463
eRtopStd 0.153088
eRtopStdnorm 0.191969
eRtopMedian 0.842105
eRtopQuartdelta 0.220192
eRtopQuartdeltanorm 0.261478
eRtopKurt 2.64178
eRtopTrenddiff 0.0321637
eRbotMean 0.940689
eRbotStd 0.580491
eRbotStdnorm 0.617092
eRbotMedian 0.777778
eRbotQuartdelta 0.735065
eRbotQuartdeltanorm 0.945083
eRbotKurt 5.10836
eRbotTrenddiff 0.00496032
eRrightMean 0.934061
eRrightStd 0.0872211
eRrightStdnorm 0.0933784
eRrightMedian 0.954545
eRrightQuartdelta 0.0857558
eRrightQuartdeltanorm 0.0898394
eRrightKurt 8.73462
eRrightTrenddiff 0.01619
eRleftMean 0.39505
eRleftStd 0.168975
eRleftStdnorm 0.42773
eRleftMedian 0.347826
eRleftQuartdelta 0.258095
eRleftQuartdeltanorm 0.742024
eRleftKurt 2.11788
eRleftTrenddiff 0.0158427
lDurationMean 0.258125
lDurationStd 0.0483894
lDurationStdnorm 0.187465
lDurationMedian 0.265
lDurationQuartdelta 0.06
lDurationQuartdeltanorm 0.226415
lDurationKurt 2.56058
lDurationTrenddiff -0.0325
lDurationTrendratio 0.881818
lWidthMean 4.52278
lWidthStd 1.95521
lWidthStdnorm 0.432303
lWidthMedian 4.329
lWidthQuartdelta 1.9305
lWidthQuartdeltanorm 0.445946
lWidthKurt 4.57878
lWidthTrenddiff 1.287
lWidthTrendratio 1.34921
lHeightMean 14.9687
lHeightStd 4.00223
lHeightStdnorm 0.267373
lHeightMedian 14.5665
lHeightQuartdelta 4.563
lHeightQuartdeltanorm 0.313253
lHeightKurt 2.93632
lHeightTrenddiff 2.808
lHeightTrendratio 1.20426
lAspectMean 0.294107
lAspectStd 0.0692006
lAspectStdnorm 0.235291
lAspectMedian 0.289675
lAspectQuartdelta 0.10635
lAspectQuartdeltanorm 0.367135
lAspectKurt 2.36032
lAspectTrenddiff 0.0195306
lAspectTrendratio 1.07066
lSlantMean 0.099968
lSlantStd 0.0752924
lSlantStdnorm 0.753165
lSlantMedian 0.110985
lSlantQuartdelta 0.119627
lSlantQuartdeltanorm 1.07787
lSlantKurt 2.13048
lSlantTrenddiff 0.0190424
lRtopMean 0.927891
lRtopStd 0.0413572
lRtopStdnorm 0.0445712
lRtopMedian 0.934409
lRtopQuartdelta 0.0495923
lRtopQuartdeltanorm 0.0530735
lRtopKurt 2.64368
lRtopTrenddiff 0.0162768
lRbotMean 0.615592
lRbotStd 0.220919
lRbotStdnorm 0.358872
lRbotMedian 0.551826
lRbotQuartdelta 0.366967
lRbotQuartdeltanorm 0.665005
lRbotKurt 2.18379
lRbotTrenddiff 0.030856
lRrightMean 0.99007
lRrightStd 0.0194798
lRrightStdnorm 0.0196752
lRrightMedian 0.992882
lRrightQuartdelta 0.0139853
lRrightQuartdeltanorm 0.0140856
lRrightKurt 20.3687
lRrightTrenddiff 0.00307597
lRleftMean 0.25405
lRleftStd 0.0694542
lRleftStdnorm 0.273388
lRleftMedian 0.257151
lRleftQuartdelta 0.0906561
lRleftQuartdeltanorm 0.35254
lRleftKurt 3.07374
lRleftTrenddiff -0.0326347

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.666565
sumTouchScores 6.66565
meanMovementTime 1.91944
numTouches 10
undershootPercentage 0
overshootPercentage 30

FITTS Long Modified

meanTouchScore 0.800053
sumTouchScores 10.4007
meanMovementTime 1.44083
numTouches 13
undershootPercentage 0
overshootPercentage 23.0769

ZigZag

numZigzags 5
timePerZigzagMean 8.552
timePerZigzagCoV 0.188355
timePerZigzagSlope -0.114593
meanError 3.29548
tremorFreq 6.05469
tremorRelPower 26.2395
tremorGyroAmpMean 0.153711
tremorGyroAmpSlope 0.00420458
tremorGyroAmpCoV 0.335577
tremorCoordAmpMean 0.51101
tremorCoordAmpSlope 0.0107838
tremorCoordAmpCoV 0.346943
tremorAccAmpMean 0.427965
tremorAccAmpSlope 0.0105977
tremorAccAmpCoV 0.334232
tremorPcRelVar 0.884601
tremorPcX 0.0805725
tremorPcY 0.996749

ZigZag Segment 1

Duration 10.08 s, Accuracy Estimate 3.159 (lower is better)

ZigZag Segment 2

Duration 9.96 s, Accuracy Estimate 3.049 (lower is better)

ZigZag Segment 3

Duration 9.0 s, Accuracy Estimate 3.016 (lower is better)

ZigZag Segment 4

Duration 7.12 s, Accuracy Estimate 3.556 (lower is better)

ZigZag Segment 5

Duration 6.6 s, Accuracy Estimate 3.697 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 7.26667
timePerZigzagCoV 0.289411
timePerZigzagSlope 0.052844
zigzagHeightMean 67.3918
zigzagHeightCoV 0.147725
zigzagHeightSlope 0.0318378
meanError 0.0445728
tremorFreq 5.37109
tremorRelPower 28.0826
tremorGyroAmpMean 0.189769
tremorGyroAmpSlope -0.00595331
tremorGyroAmpCoV 0.358397
tremorCoordAmpMean 0.75475
tremorCoordAmpSlope 0.00717328
tremorCoordAmpCoV 0.521582
tremorAccAmpMean 0.658964
tremorAccAmpSlope 0.00671623
tremorAccAmpCoV 0.488518
tremorPcRelVar 0.952862
tremorPcX 0.00489
tremorPcY 0.999988

ZigZag Offset Segment 1

Duration 6.8 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 2

Duration 6.48 s, Accuracy Estimate 0.042 (lower is better)

ZigZag Offset Segment 3

Duration 4.68 s, Accuracy Estimate 0.054 (lower is better)

ZigZag Offset Segment 4

Duration 8.88 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 5

Duration 10.56 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 6

Duration 6.2 s, Accuracy Estimate 0.058 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.69}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.6606135061705045}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8523314605194667}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}